Verified answer

The simplest way to travel from SF to San Leandro is by BART

You can take the train from several points in SF and it makes 2 stops in San Leandro.

There is a ferry from San Francisco to Oakland (or at least there was when I was last there) but it's for commuters and probably not convenient (check the schedule). I drove in the Bay Area for 35 years and do not recommend renting a car for the uninitiated & unarmed. BART is a relatively clean & safe electric train system, so I'd recommend you take BART from one of the Market Street stations (they're all under ground but fairly easy to find) to the San Leandro station (it's above ground and smells a bit better). From there you can catch an AC Transit bus or get a cab.

Definitely BART. It's the cheapest and fastest way to get around. As there are two stops in San Leandro, its a fairly safe bet that atleast one of them gets you close to where you'd like to be. BART is almost always on time though, so if you've got a schedule make sure your at the station because you will get left.

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BART!